1. Accelerated radiotherapy delivery has recently been shown to be effective in overcoming repopulation during fractionated radiotherapy.

2. His palæontological work in the 1790s had established the reality of extinction, which he explained by local catastrophes, followed by repopulation of the affected areas by other species.

3. The analytical/graphical method employed to fit the clinical data allowed us to estimate the intrinsic tumor radiosensitivity (α), repair capability (b), and repopulation doubling time (Td) in a first phase, and subsequently the number of clonogens (N) and kick-off time for accelerated proliferation (Tk).